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Updated: May 2, 2026
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
The first report on flavonoid isolation from Annona crassiflora Mart
Gisele Avelar Lage1, Felipe da Silva Medeiros, Werônica de Lima Furtado
1a Departamento de Química , Instituto de Ciências Exatas, Universidade Federal de Minas Gerais , Av. Antînio Carlos, 6627, Belo Horizonte , Minas Gerais CEP 31270-901 , Brazil.
Abstract:
Annona crassiflora, a native tree from Brazilian Cerrado, is reported to possess several ethnomedical uses. Here, we report the isolation and unambiguous characterisation of the flavonoids quercetin-3-O-β-D-glucopyranosil(1 → 6)-O-α-L-arabinoside (1), known as peltatoside, kaempferol-3-O-β-D-galactopyranoside (2), quercetin-3-O-β-D-galactopyranoside (3), quercetin-3-O-β-L-arabinopiranoside (4) and the ( - )-epicatechin (5) from the hydroalcoholic portion of the leaf ethanolic extract. Their structures were elucidated by using 1D and 2D NMR, ESI-MS, UV/Vis spectroscopy, optical rotation analysis and literature data comparison. The leaf ethanolic extract and its isolated compounds were evaluated by using antimicrobial, antioxidant and larvicidal assays, expressing antimicrobial and antioxidant activities. This is the first report on flavonoid isolation from A. crassiflora.
