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Updated: May 2, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Heterotopic ossification after total hip replacement
S C Kirshblum1, D I Campagnolo1
1Kessler Institute for Rehabilitation, West Orange, NJ University of Medicine and Dentistry/New Jersey Medical School, Newark, NJ.
Abstract:
Heterotopic ossification (HO) is a common finding after total hip arthroplasty (THA), and may cause diminished hip range of motion and an antalgic gait. Although the etiology remains unclear, two theories currently prevail. In this article, the incidence, etiology, risk factors, and classifications of HO are discussed. Effective prophylactic treatments including radiation and anti-inflammatory medications are detailed. Once HO is present, the value of these treatments are doubtful and surgical excision may be required after bony maturity. With increasing THA projected as the population ages, the need for safe, effective, and inexpensive prophylaxis may be required.
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