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Updated: May 2, 2026

Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs

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Published on: June 20, 2016

[Targeted genome modifications using TALEN].

Barbara Dupret¹, Pierre-Olivier Angrand²

¹Inserm U908, université de Lille 1, bâtiment SN3, Cité scientifique, 59655 Villeneuve d'Ascq, France.

Medecine Sciences : M/S

|February 28, 2014

Summary

Transcription activator-like effector nucleases (TALEN) enable precise genome editing. These engineered molecular scissors facilitate rapid and efficient genetic modifications across diverse cell types and organisms, advancing biotechnology and biomedical research.

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Area of Science:

Biotechnology and Biomedical Research
Molecular Biology
Genomics

Context:

Genome editing is a critical goal in biological sciences.
Transcription activator-like effectors (TALE) have been recently discovered.
Customized TALEN have been engineered for precise genetic manipulation.

Purpose:

To introduce the application of TALEN technology in genome editing.
To highlight the capabilities of TALEN as molecular scissors.
To discuss the potential of TALEN in various research models.

Summary:

TALEN are engineered nucleases derived from transcription activator-like effectors.
They function as molecular scissors to induce specific and efficient genomic modifications.
This technology enables rapid genome editing in diverse cell types and model organisms.

Impact:

TALEN offer a powerful tool for advancing genetic research.
They hold significant promise for future applications in biological and medical fields.
Facilitates precise genetic modifications for a wide range of research purposes.