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Updated: May 2, 2026

Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs
Published on: June 20, 2016
[Targeted genome modifications using TALEN]
Barbara Dupret1, Pierre-Olivier Angrand2
1Inserm U908, université de Lille 1, bâtiment SN3, Cité scientifique, 59655 Villeneuve d'Ascq, France.
Abstract:
Precise modifications of genomes have been one of the biggest goals in the fields of biotechnology and biomedical research. Recent discovery of TALE (transcription activator-like effectors) and the engineering of customized TALEN (transcription activator-like effector nucleases) allowed rapid genome editing in a variety of cell types and different model organisms. TALEN are molecular scissors used to induce a wide range of specific and efficient genomic modifications. TALEN promise to have profound impacts on biological and medical research over the coming years.
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