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Related Concept Videos

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Related Experiment Video

Updated: May 2, 2026

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
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Developing cellular therapies for retinal degenerative diseases.

Kapil Bharti1, Mahendra Rao, Sara Chandros Hull

  • 1Unit on Ocular and Stem Cell Translational Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Investigative Ophthalmology & Visual Science
|February 28, 2014
PubMed
Summary
This summary is machine-generated.

Stem cell therapies show promise for degenerative eye diseases like AMD. Sharing information in the "precompetitive space" can accelerate the development of these treatments for vision restoration.

Keywords:
age-related macular degenerationcell-based therapyretinitis pigmentosastem cells

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Area of Science:

  • Ophthalmology and Regenerative Medicine
  • Biomedical Engineering

Background:

  • The visual system's accessibility facilitates research, enabling advances like stem cell therapies for degenerative eye diseases.
  • Stem cell-based treatments are emerging for conditions such as age-related macular degeneration (AMD).

Purpose of the Study:

  • To discuss the development of cellular therapies for retinal degenerative diseases.
  • To emphasize the value of information sharing in the "precompetitive space" to overcome clinical development hurdles.

Main Methods:

  • Review of ongoing clinical trials using various stem cell types (embryonic, induced pluripotent, mesenchymal, progenitor, adult RPE).
  • Discussion of common principles, concerns, and issues in the clinical development pipeline for ocular stem cell therapies.

Main Results:

  • Two Phase I clinical trials using embryonic stem cell-derived retinal pigment epithelium (RPE) are active.
  • Multiple trials using diverse stem cell sources are in earlier developmental stages.

Conclusions:

  • Collaborative information sharing in the "precompetitive space" can streamline the advancement of stem cell therapies for retinal diseases.
  • The developed model for information sharing may benefit broader scientific applications beyond ophthalmology.