Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

71.5K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
71.5K
Protein and Protein Structures02:15

Protein and Protein Structures

14.6K
14.6K
Protein Organization01:24

Protein Organization

7.2K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
7.2K
Protein Organization01:13

Protein Organization

123.3K
Overview
123.3K
Protein Organization01:24

Protein Organization

9.0K
9.0K
Protein Organization01:13

Protein Organization

19.5K
19.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different genomic footprint of small insertion-deletion and structural variants determines the genetic divergence of indica and japonica rice.

BMC genomics·2026
Same author

RNAbpFlow: base pair-augmented SE(3) flow matching for conditional RNA 3D structure generation.

Nature methods·2026
Same author

ORIGAMI: Orientation-Aware Graph Neural Network for Assessing Multimeric Interfaces of Protein Complex Structures.

bioRxiv : the preprint server for biology·2026
Same author

A unified multimodal model for generalizable zero-shot and supervised protein function prediction.

Bioinformatics (Oxford, England)·2026
Same author

CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs.

Briefings in bioinformatics·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: May 2, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

70.1K

The MULTICOM protein tertiary structure prediction system.

Jilong Li1, Debswapna Bhattacharya, Renzhi Cao

  • 1Computer Science Department, C. Bond Life Science Center, Informatics Institute, University of Missouri, Columbia, MO, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 28, 2014
PubMed
Summary
This summary is machine-generated.

MULTICOM is a novel computational technique for predicting protein structures. It combines multiple data sources to achieve moderate- to high-resolution protein structure prediction, advancing structural genomics.

More Related Videos

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

1.3K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K

Related Experiment Videos

Last Updated: May 2, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

70.1K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

1.3K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K

Area of Science:

  • Structural biology
  • Computational biology
  • Genomics and proteomics

Background:

  • Advancements in next-generation sequencing have led to vast amounts of genomics and proteomics data.
  • Computational prediction of protein three-dimensional structure is crucial for structural genomics.
  • Understanding the protein sequence-structure relationship remains a significant challenge in life sciences.

Purpose of the Study:

  • To introduce MULTICOM, a multi-level combination technique for protein structure prediction.
  • To address the challenge of predicting protein structure from sequence.
  • To provide a novel approach combining multiple information sources for improved prediction accuracy.

Main Methods:

  • Developed a multi-level combination technique named MULTICOM.
  • Integrated complementary information derived from experimentally solved protein structures in the Protein Data Bank.
  • Utilized a novel approach for combining diverse data sources.

Main Results:

  • MULTICOM is designed to predict protein structures at moderate to high resolution.
  • The technique leverages multiple sources of information for enhanced prediction.
  • A web server for MULTICOM is available for public use.

Conclusions:

  • MULTICOM offers a new strategy for computational protein structure prediction.
  • The method combines diverse data to improve the accuracy of structure prediction.
  • This approach contributes to the field of structural genomics and computational biology.