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Updated: May 2, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Molecular therapies in hepatocellular carcinoma: what can we target?

Roberto Galuppo1, Dinesh Ramaiah, Oscar Moreno Ponte

  • 1Division of Transplantation Surgery, Department of Surgery, College of Medicine, University of Kentucky, 800 Rose Street, Room C453, Lexington, KY, 40536-0293, USA.

Digestive Diseases and Sciences
|February 28, 2014
PubMed

Insights

Molecular targeted therapies are advancing the treatment of hepatocellular carcinoma (HCC). Research is exploring novel signaling pathways and combination therapies to improve outcomes for advanced liver cancer.

Area of Science:

  • Oncology
  • Hepatology
  • Molecular Biology

Background:

  • Hepatic carcinogenesis involves multiple signaling pathways, including Ras/Raf/MAPK.
  • Hepatocellular carcinoma (HCC) management is evolving with new therapeutic strategies.

Purpose of the Study:

  • To review the advancements in molecular targeted therapies for hepatocellular carcinoma.
  • To highlight the ongoing research in combination therapies for advanced HCC.

Main Methods:

  • Review of ongoing clinical trials for advanced HCC.
  • Analysis of molecular targeted therapies inhibiting key signaling pathways.

Main Results:

  • Numerous combination therapy studies (over 35) are underway for advanced HCC.
  • Development of sorafenib has spurred further research into novel molecular targets.

Conclusions:

  • Molecular targeted therapies represent a significant shift in HCC management.
  • Inhibition of diverse signaling pathways offers potential for improved hepatocarcinogenesis treatment.

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