Related Experiment Video
Updated: May 2, 2026
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Published on: May 10, 2012
Simultaneous functional MRI acquisition of distributed brain regions with high temporal resolution using a
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Neuroimage Nord, University Medical Centers Hamburg-Kiel-Lübeck, Germany.
Purpose:
To perform simultaneous functional MRI of multiple, distributed brain regions at high temporal resolution using a 2D-selective radiofrequency (2DRF) excitation.
Methods:
A tailored 2DRF excitation is used to excite several, small regions-of-interest distributed in the brain. They are acquired in a single projection image with an appropriately chosen orientation such that the different regions-of-interest can be discriminated by their position in the projection plane. Thus, they are excited and acquired simultaneously with a temporal resolution comparable to that of a single-slice measurement. The feasibility of this approach for functional neuroimaging (in-plane resolution 2 × 2 mm(2) ) at high temporal resolution (80 ms) is demonstrated in healthy volunteers for regions-of-interest in the visual and motor system using checkerboard and finger tapping block-design paradigms.
Results:
Task-related brain activation could be observed in both the visual and the motor system simultaneously with a high temporal resolution. For an onset shift of 240 ms for half of the checkerboard, a delay of the hemodynamic response in the corresponding hemisphere of the visual cortex could be detected.
Conclusion:
Limiting the excited magnetization to the desired target regions with a 2DRF excitation reduces the imaging sampling requirements which can improve the temporal resolution significantly.
