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Updated: May 2, 2026

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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Supramolecular nanofibrils inhibit cancer progression in vitro and in vivo

Yi Kuang1, Xuewen Du, Jie Zhou

  • 1Brandeis University, 415 South St., MS 015, Waltham, MA, 02453, USA.

Advanced Healthcare Materials
|February 28, 2014
PubMed

Insights

Researchers developed novel peptide-based nanofibrils that mimic amyloid oligomers. These structures show promise as a new anticancer therapy by inhibiting tumor progression in vitro and in vivo.

Area of Science:

  • Biochemistry
  • Materials Science
  • Oncology

Background:

  • Amyloid oligomers are implicated in neurodegenerative diseases.
  • Peptide self-assembly can create ordered nanostructures.

Purpose of the Study:

  • To investigate the potential of de novo amyloid-like oligomers for cancer therapy.
  • To explore the anticancer efficacy of self-assembled peptide nanofibrils.

Main Methods:

  • Synthesis of peptide derivatives capable of self-assembly.
  • Characterization of self-assembled nanofibrils.
  • In vitro and in vivo evaluation of anticancer activity.

Main Results:

  • Peptide derivatives self-assembled into supramolecular nanofibrils with amyloid oligomer characteristics.
  • These nanofibrils effectively inhibited tumor progression in both in vitro and in vivo models.
  • Demonstrated a novel anticancer approach using de novo amyloid oligomers.

Conclusions:

  • Self-assembled peptide nanofibrils represent a promising new strategy for cancer treatment.
  • This work may offer insights into the inverse comorbidity between cancer and neurodegenerative diseases.
Keywords:
anticancerde novo amyloidinverse comorbiditynanofibrilssupramolecular

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