Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles
Ming Wang1, Kyle Alberti, Antonio Varone
1Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.
Advanced Healthcare Materials
|February 28, 2014
Abstract:
A new library of lipid-like nanoparticles (lipidoids) comprising disulfide bond is developed for siRNA delivery. Bioreducible lipidoids deliver siRNA with greater efficiency than nonbioreducible lipidoids with similar chemical structures. A siRNA release investigation, as well as an intracellular siRNA trafficking study, reveals that the degradation of bioreducible lipidoid in a strongly reductive intracellular environment boosts siRNA release and enhances siRNA gene knockdown efficiency.


