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A study of leptin serum concentrations in patients with major Beta-thalassemia
I Shahramian1, E Akhlaghi2, A Ramezani3
1Assistant Professor of Pediatric, Department of Pediatrics, Zabol University of Medical Sciences, Zabol , Iran.
Insights
Major beta thalassemia significantly reduces serum leptin levels in children. This study found an inverse correlation between leptin and ferritin levels in these patients.
Area of Science:
- Hematology
- Endocrinology
- Pediatrics
Background:
- Major beta thalassemia is a severe inherited blood disorder.
- Altered metabolic profiles are common in thalassemia patients.
- Leptin and ferritin levels are potential biomarkers for metabolic disturbances.
Purpose of the Study:
- To investigate serum leptin levels in children with major beta thalassemia.
- To examine the association between leptin and ferritin serum levels in this cohort.
Main Methods:
- A case-control study involving 90 children (6 months to 16 years).
- Serum leptin and ferritin levels were measured using ELISA.
- Statistical analysis was performed using SPSS 20.
Main Results:
- Significant differences in serum leptin and ferritin levels were observed between thalassemia patients and controls (P<0.05).
- An inverse correlation was found between serum leptin and ferritin levels (P<0.05).
- Leptin levels showed a significant gender difference in the thalassemia group, but not by BMI or age.
Conclusions:
- Major beta thalassemia is associated with reduced serum leptin levels, independent of age and BMI.
- An inverse relationship exists between serum leptin and ferritin in children with major beta thalassemia.
Background:
The aim of this study was to evaluate leptin serum levels in patients with major beta thalassemia which was also associated with their ferritin serum levels.
Materials And Methods:
This case-control study was performed on 90 children -6 months to 16 years old, in Zabol, Amir- al- Momenin Hospital. Patients were divided in two groups and were matched in age and sex. All Children were examined and those eligible children who had not known heart disease, iron deficiency anemia, kidney disease, diabetes, fever and systemic diseases were enrolled after taking the informed consent of their parents. After collecting the samples, leptin and ferritin levels of the serum were measured in two groups by ELISA method. Then, the data was analyzed by the related statistical tests and SPSS 20 software.
Results:
The mean of the serum levels of leptin and ferritin showed a significant difference in the case and control groups (P-value<0.05). An inverse statistical correlation was found for the serum levels of leptin and ferritin among the studied groups (P-value<0.05). Levels of leptin in the case group showed a significant gender difference (P-value<0.05), while based on BMI and age, no significant difference was observed for the serum levels of leptin in the case group.
Conclusion:
Based on the results of this study, major thalassemia reduces serum levels of leptin regardless of age and body mass. The study also found an inverse statistical correlation between serum levels of leptin and ferritin among the studied people.
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