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Related Concept Videos

Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

279
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
279
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.1K
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

222
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

308
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
308

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Improving Lurasidone Hydrochloride's Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin.

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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
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Preface for buccal drug delivery theme issue.

Javier Octavio Morales1, Jason Thomas McConville

  • 1Department of Pharmaceutical Sciences and Technology, University of Chile , Santiago , Chile and.

Drug Development and Industrial Pharmacy
|March 1, 2014
PubMed
Summary
This summary is machine-generated.

Buccal drug delivery offers an alternative to oral administration, bypassing the gastrointestinal tract for improved drug absorption. This special edition explores advancements in buccal delivery systems, including nanotechnology, for enhanced therapeutic outcomes.

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Area of Science:

  • Pharmacology and Pharmaceutics
  • Drug Delivery Systems

Background:

  • Buccal drug delivery is explored as an alternative to oral administration.
  • It bypasses the gastrointestinal tract's acidic environment, enzymatic activity, and first-pass metabolism.
  • This route is suitable for macromolecules and drugs incompatible with the GI tract.

Discussion:

  • This special edition compiles reviews and original research on buccal drug delivery.
  • It covers prominent features and systems within the growing field.
  • Nanotechnology's role in facilitating buccal drug delivery is a key focus.

Key Insights:

  • Buccal administration avoids hepatic first-pass metabolism and GI degradation.
  • It offers enhanced bioavailability for certain drug classes.
  • Nanotechnology presents novel strategies for effective buccal drug delivery.

Outlook:

  • Future product development in buccal drug delivery is anticipated.
  • Continued research into nanotechnology will drive innovation.
  • The buccal route holds significant potential for alternative drug administration.