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6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists
M E Flaugh1, D L Mullen, R W Fuller
1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Journal of Medicinal Chemistry
|September 1, 1988
Abstract:
A series of 6-substituted tricyclic ergoline partial structures has been synthesized and found to possess very strong serotonin agonist activity. A methoxy group at the 6-position greatly enhances activity, but at the expense of compound stability. Substituting the 6-position with protophyllic groups that are also electron-withdrawing in character enhances both activity and stability.