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Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

T Hiraoka1, K Miyata2, Y Nakamura2

  • 1Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Eye (London, England)
|March 1, 2014
PubMed

Insights

Cycloplegia with cyclopentolate significantly increases ocular higher-order aberrations (HOAs) in myopic children, while corneal HOAs remain unchanged. Internal optics compensate for corneal HOAs, but significant individual variations exist.

Area of Science:

  • Ophthalmology
  • Optometry
  • Pediatric Eye Care

Background:

  • Myopia is a common refractive error in children.
  • Understanding wavefront aberrations is crucial for myopia management.
  • The effect of cycloplegia on ocular aberrations in pediatric myopia requires further investigation.

Purpose of the Study:

  • To determine how topical cyclopentolate-induced cycloplegia impacts wavefront aberrations in myopic children.
  • To compare ocular and corneal aberrations before and after cycloplegia.
  • To analyze individual Zernike components of aberrations.

Main Methods:

  • Prospective, comparative study involving 28 myopic children (mean age 7.25 ± 2.55 years).
  • Measurement of refraction and wavefront aberrations (ocular and corneal) using Zernike analysis up to the sixth order, before and after 1% cyclopentolate hydrochloride administration.
  • Comparison of pre- and post-cycloplegia parameters.

Main Results:

  • Ocular higher-order aberrations (HOAs), including spherical-like and total HOAs, significantly increased post-cycloplegia (P=0.012 and P=0.015, respectively).
  • Corneal HOAs showed no significant change after cycloplegia.
  • Ocular HOAs were significantly smaller than corneal HOAs for spherical-like (P<0.001) and total HOAs (P=0.006).
  • Individual Zernike components generally showed smaller or equivalent ocular values compared to corneal values, with large inter-individual standard deviations.

Conclusions:

  • The internal optics of the eye compensate for corneal higher-order aberrations in myopic children.
  • Cyclopentolate-induced paralysis of tonic accommodation significantly influences ocular HOAs.
  • There is substantial inter-individual variability in Zernike components among myopic children.
Abstract

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