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Updated: May 2, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Metabolic syndrome and longitudinal changes in cognitive function: a systematic review and meta-analysis
Mario Siervo1, Stephanie L Harrison1, Carol Jagger1
1Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
Metabolic syndrome (MetS) is linked to cognitive decline, particularly in individuals under 70. Age modifies this association, highlighting the need for age-specific dementia risk models in those with metabolic disorders.
Area of Science:
- Neurology
- Gerontology
- Metabolic Disorders
Background:
- Metabolic syndrome (MetS) is a known risk factor for cardiovascular diseases and stroke.
- Previous research on MetS and cognitive decline has yielded inconsistent findings.
Purpose of the Study:
- To investigate the association between MetS and longitudinal changes in cognitive function.
- To explore potential age-related differences in this association.
Main Methods:
- A systematic review and meta-analysis of longitudinal cohort studies.
- Searched Medline, EMBASE, and Scopus databases up to June 2013.
- Included 13 studies with a total of 19,522 participants and follow-up durations from 1 to 16 years.
Main Results:
- A small but significant association was found between MetS and cognitive decline overall (SDM = 0.06).
- A marginal association was observed in younger old individuals (≤70 years; SDM = 0.09).
- No significant association was found in older individuals (>70 years; SDM = 0.03).
Conclusions:
- Age significantly modifies the relationship between MetS and cognitive decline.
- Age-stratified risk prediction models are crucial for dementia risk assessment in individuals with metabolic disorders.
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