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Novel t(2;12)(q31;p13) in a case of pediatric T-cell acute lymphoblastic leukemia
Mayur Parihar1, Anurag Gupta, Arun S Remani
1Departments of *Cytogenetics †Pediatric Hematology ‡Lab Hematology §Clinical Hematology, Tata Medical Center, Kolkata, India.
Background:
The role of ETV6 in B-cell acute lymphoblastic leukemia (ALL) has been extensively studied, whereas only rare cases of ETV6 involvement in pediatric T-cell ALL have been described.
Observation:
We report a case of T-cell ALL in a 13-year-old boy with t(2;12)(q31;p13) involving ETV6, resulting in the relocation of the ETV6 from 12p13 to 2q31 locus that harbors the class 1 homeobox gene (HOX) cluster D, which is expressed during the early stages of T-cell development.
Conclusions:
We report a novel translocation in T-cell ALL highlighting the involvement of ETV6 and potentially the HOXD gene cluster in a case of T-cell ALL.
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