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Updated: May 2, 2026
08:58
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
882
Bronchopulmonary dysplasia: clinical perspective.
Deepak Jain1, Eduardo Bancalari
1University of Miami, Miami, Florida.
Summary
Bronchopulmonary dysplasia (BPD) now primarily affects extremely premature infants due to antenatal and postnatal factors impacting lung development. Effective prevention and treatment require a multi-pronged strategy, as single therapies are unlikely to eliminate this complex condition.
Area of Science:
- Neonatology
- Pediatric Pulmonology
- Developmental Biology
Background:
- Bronchopulmonary dysplasia (BPD) has evolved from its original description, now predominantly affecting extremely premature infants.
- The condition results from antenatal and postnatal factors causing lung injury and impaired alveolar and vascular development.
- Understanding the multifactorial pathogenesis of BPD is crucial for advancing care.
Purpose of the Study:
- To review the evolution of Bronchopulmonary dysplasia (BPD) clinical presentation.
- To summarize current knowledge on BPD pathogenesis and contributing factors.
- To discuss the efficacy of various prevention and management strategies for BPD.
Main Methods:
- Literature review and synthesis of existing research on Bronchopulmonary dysplasia (BPD).
- Analysis of factors contributing to BPD development and altered lung development.
- Evaluation of evidence for different therapeutic interventions in BPD management.
Main Results:
- Several strategies, including vitamin A, postnatal steroids, caffeine, and volume-targeted ventilation, have shown success in clinical trials.
- Evidence for other interventions in managing BPD is limited or negative.
- A single therapeutic approach is insufficient to eradicate BPD without addressing prematurity.
Conclusions:
- Bronchopulmonary dysplasia (BPD) management requires a comprehensive strategy targeting multiple aspects of the disease process.
- Novel therapeutic agents acting at various stages are needed for future advancements in BPD prevention and treatment.
- Reducing prematurity remains a critical factor in combating BPD.
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