Related Experiment Video

Updated: May 2, 2026

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

8.0K

Barriers to liver transplantation in HIV infected patients

C Wyndham-Thomas1, M Delforge2, J P Mulkay2

  • 1Division of Infectious disease, CHU Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium. cwyndham@ulb.ac.be

Acta Clinica Belgica
|March 4, 2014
PubMed

Insights

Barriers limit liver transplantation for HIV patients with liver disease, with few meeting criteria for listing. Early referral and awareness are crucial for successful outcomes in this population.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Liver disease is a leading cause of non-AIDS mortality in HIV patients.
  • Liver transplantation offers a therapeutic option for advanced liver disease in HIV patients.
  • Limited data exists on liver transplantation barriers for HIV patients in specific cohorts.

Purpose of the Study:

  • To identify barriers to liver transplantation in HIV patients within the Brussels Saint-Pierre HIV Cohort.
  • To analyze reasons for patient exclusion from liver transplant candidacy.
  • To assess the impact of HIV and non-HIV related factors on transplant eligibility.

Main Methods:

  • Retrospective review of HIV patients with a theoretical indication for liver transplantation (01/01/2002-01/07/2010).
  • Classification of reasons for not being listed as candidates (HIV-related, non-HIV related, multifactorial).
  • Analysis of patient demographics, co-infections (HBV/HCV), and reasons for non-candidacy.

Main Results:

  • Nineteen patients with HBV and/or HCV co-infection were identified.
  • Major reasons for non-candidacy included non-adherence, alcohol abuse, psychiatric disease, and hepatotoxicities.
  • Only one of three potential candidates was listed, dying before transplant; others chose alternative treatments.

Conclusions:

  • Few HIV patients with indications for liver transplantation meet the criteria for enlistment.
  • Barriers such as non-adherence, substance abuse, and comorbidities significantly impact candidacy.
  • Increased awareness and early referral are essential to improve pre-transplant management and transplant rates for HIV patients with end-stage liver disease.
Abstract

More Related Videos

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.7K
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

2.9K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
827
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
86
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271