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Updated: May 2, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

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Published on: August 21, 2016

[Characterization and identification of functional elements in non-coding DNA sequences].

Dan Qin¹, Cun-Shuan Xu²

¹College of Life Science, Henan Normal University, Xinxiang 453007, China. qindan2008@126.com

Yi Chuan = Hereditas

|March 4, 2014

Summary

This summary is machine-generated.

Non-coding DNA sequences regulate gene expression by binding transcription factors or forming functional RNAs. This review covers their structures, functions, mechanisms, and identification methods.

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An Integrated Approach for Microprotein Identification and Sequence Analysis

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Published on: July 12, 2022

Area of Science:

Genomics
Molecular Biology
Epigenetics

Context:

Non-coding DNA comprises a significant portion of the genome, historically termed 'junk DNA'.
Emerging evidence highlights critical roles for non-coding DNA in gene regulation.
Understanding these sequences is key to deciphering complex biological processes.

Purpose:

To review recent advancements in the study of non-coding DNA.
To elucidate the structures, functions, and regulatory mechanisms of non-coding DNA.
To introduce methods for identifying functional elements within non-coding DNA.

Summary:

Non-coding DNA sequences, which do not code for proteins, are crucial regulators of gene expression.
They function by interacting with transcription factors or being transcribed into functional RNAs.
This review details their diverse roles in physiological and pathological processes.

Impact:

Provides a comprehensive overview of non-coding DNA research.
Highlights the importance of non-coding DNA in gene expression regulation.
Suggests future research directions for this rapidly evolving field.