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MicroRNAs in bladder cancer: expression profiles, biological functions, regulation, and clinical implications

Zhaoqi Shi1, Qingxia Wei2, Mingxin Zhang3

  • 1Department of General Surgery, 1st Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710061, Shaan'xi Province, China.

Critical Reviews in Eukaryotic Gene Expression
|March 4, 2014
PubMed

Insights

MicroRNAs (miRNAs) play key roles in bladder cancer (UBC) progression. Understanding their deregulation offers insights into UBC mechanisms and potential diagnostic markers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer (UBC) is a prevalent malignancy with high recurrence rates.
  • The molecular underpinnings of UBC remain incompletely elucidated.
  • MicroRNAs (miRNAs) are small noncoding RNAs crucial in cellular processes.

Purpose of the Study:

  • To review miRNA expression profiles, biological functions, and regulation in UBC.
  • To explore the clinical implications of miRNAs in UBC.
  • To highlight the potential of miRNAs as diagnostic and prognostic biomarkers.

Main Methods:

  • Literature review of studies on miRNA expression and function in UBC.
  • Analysis of miRNA deregulation mechanisms (epigenetic changes, biogenesis defects).
  • Examination of miRNA involvement in UBC hallmarks (proliferation, apoptosis, metastasis, drug resistance).

Main Results:

  • miRNA expression is frequently altered in UBC.
  • miRNA deregulation impacts critical UBC progression pathways.
  • Specific miRNAs, including those in urine, correlate with tumor characteristics and patient survival.

Conclusions:

  • miRNAs are significantly implicated in the development and progression of UBC.
  • miRNAs hold promise as novel diagnostic and prognostic tools for bladder cancer.
  • Further research into miRNA roles will advance understanding of UBC molecular mechanisms.

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