A complete structural performance analysis and modelling of hydroxyapatite scaffolds with variable porosity

Area of Science:

• Biomaterials Science
• Materials Engineering
• Orthopedic Research

Background:

• Hydroxyapatite (HA) scaffolds are explored for bone regeneration in defects from disease or trauma.
• Existing literature shows variability in HA scaffold mechanical performance.
• A comprehensive analysis is needed to address these mechanical performance disparities.

Purpose of the Study:

• To conduct a complete analysis of the structural performance of porous HA scaffolds.
• To compare experimental, numerical, and theoretical predictions of mechanical properties.
• To validate predictive models for HA scaffold mechanical behavior.

Main Methods:

• Fabrication of HA scaffolds with variable porosity using the water-soluble polymer method.
• Characterization via scanning electron microscopy, stereo microscopy, X-ray diffraction, porosity analysis, and mechanical testing.
• Finite element method simulations and theoretical predictions using the Gibson and Ashby model.

Main Results:

• Experimental characterization of HA scaffolds with varying porosity.
• Numerical and theoretical models were developed to predict mechanical properties.
• Comparison of experimental, numerical, and theoretical results demonstrated good agreement.

Conclusions:

• The developed numerical and theoretical models accurately predict the mechanical performance of HA scaffolds.
• These models are reliable for assessing HA scaffolds with different porosity values.
• This research contributes to optimizing HA scaffold design for bone regeneration.