Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.5K
Adrenergic Neurons: Neurotransmission01:27

Adrenergic Neurons: Neurotransmission

5.4K
Postganglionic sympathetic fibers (except those supplying the sweat glands) releasing noradrenaline or norepinephrine are called noradrenergic or adrenergic neurons. Noradrenaline, dopamine, adrenaline, or epinephrine are collectively called "catecholamines" as they contain a catechol moiety and an amine side chain. The five stages of neurotransmitter release involve their synthesis, storage, release, reuptake and metabolism.
Synthesis: Catecholamine synthesis requires tyrosine, which...
5.4K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.8K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.8K
Amyloid Fibrils03:03

Amyloid Fibrils

10.2K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Composite severity score for race-related incidents in cycling.

British journal of sports medicine·2026
Same author

Lower Urinary Tract Symptoms (LUTSs) in Elite Female and Male Athletes: Prevalence and Impact on Performance-A Cross-Sectional Study Using the STROBE-SIIS (Sports Injury and Illness Surveillance) Reporting Guidelines.

Epidemiologia (Basel, Switzerland)·2026
Same author

Steering the Shape-shifting of Bullvalene-Pd<sup>II</sup> Complexes Through Steric and Geometric Strain.

Angewandte Chemie (International ed. in English)·2026
Same author

Squash Under Strain: A Systematic Review and Meta-Analysis of Injuries and Illnesses in Squash Players.

Sports (Basel, Switzerland)·2026
Same author

Development of a secure, standardised and interoperable surveillance platform for race-related injury and illness data within the UCI men's and women's road cycling world tour: a study protocol.

BMJ open sport & exercise medicine·2026
Same author

Paramagnetic Complexes of Expanded Cage Amine Ligands.

Inorganic chemistry·2026

Related Experiment Video

Updated: May 2, 2026

Calcium Imaging of Cortical Neurons using Fura-2 AM
12:15

Calcium Imaging of Cortical Neurons using Fura-2 AM

Published on: January 19, 2009

62.2K

Furanodendralenes.

Thomas Fallon1, Anthony C Willis, Michael N Paddon-Row

  • 1Research School of Chemistry, The Australian National University , Canberra, Australian Capital Territory 0200, Australia.

The Journal of Organic Chemistry
|March 4, 2014
PubMed
Summary
This summary is machine-generated.

Diels-Alder reactions involving furan-containing dendralene analogues yield complex molecular structures. This study charts the site and stereoselectivity, enabling efficient synthesis of complex compounds.

More Related Videos

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
09:37

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs

Published on: August 31, 2009

26.0K
Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

4.7K

Related Experiment Videos

Last Updated: May 2, 2026

Calcium Imaging of Cortical Neurons using Fura-2 AM
12:15

Calcium Imaging of Cortical Neurons using Fura-2 AM

Published on: January 19, 2009

62.2K
Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
09:37

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs

Published on: August 31, 2009

26.0K
Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

4.7K

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Reaction Mechanisms

Background:

  • Dendralenes are conjugated polyenes with potential applications in materials science.
  • Furan derivatives are versatile building blocks in organic synthesis.
  • Diels-Alder reactions are powerful tools for constructing cyclic systems.

Purpose of the Study:

  • To investigate the Diels-Alder reactivity of furan-containing dendralene analogues.
  • To elucidate the site and stereoselectivity of these reactions.
  • To develop rapid synthetic routes to complex molecular architectures.

Main Methods:

  • Synthesis of furan-containing dendralene analogues.
  • Diels-Alder cycloaddition reactions with various dienophiles.
  • Spectroscopic analysis (NMR, MS) for structural characterization.
  • Stereochemical analysis to determine product configurations.

Main Results:

  • Complex reaction sequences were observed for the Diels-Alder reactions.
  • High site selectivity was determined for the cycloaddition.
  • Specific stereochemical outcomes were elucidated.
  • Rapid access to highly complex molecular structures was achieved.

Conclusions:

  • Furan-containing dendralene analogues are valuable substrates for Diels-Alder reactions.
  • These reactions provide a powerful strategy for synthesizing complex molecules.
  • The inherent selectivity of these processes facilitates efficient synthetic design.