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Interferons as gene activators: close linkage of two interferon-activatable murine genes
D A Engel1, J Snoddy, E Toniato
1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511.
Virology
|September 1, 1988
Abstract:
Previously we have identified a mouse genomic clone (clone 5) which specifies the 5' flanking region and the 5' terminal exon of an interferon-activatable gene (202 gene). Here, we show that about 5 kb upstream from this flanking region in clone 5 there occurs a 3' terminal region of a second interferon-activatable gene (203 gene). The two genes are transcribed in the same direction. Segments from the 203 gene can be hybridized to a set of five interferon-inducible RNAs. The 203 mRNAs are induced about 15-fold in interferon-treated Ehrlich ascites tumor cells.