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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
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Evaluating implants in orthopaedic trials: tips for conducting research.

Simrit Bains1, Beate Hanson2, Mohit Bhandari3

  • 1Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Journal of Long-Term Effects of Medical Implants
|March 4, 2014
PubMed
Summary

Conducting high-quality orthopaedic implant research is challenging but essential. This article offers practical solutions for overcoming common obstacles in randomized trials, improving evidence validity for clinical practice.

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Area of Science:

  • Orthopaedic Surgery
  • Clinical Research Methodology

Background:

  • Quality research on orthopaedic implants is crucial for clinical practice but often lacking.
  • Observational studies are more common than randomized trials, offering less robust evidence.
  • Orthopaedic clinicians face unique challenges in conducting randomized trials, including randomization, blinding, and follow-up.

Purpose of the Study:

  • To identify and address the challenges in conducting high-quality randomized trials for orthopaedic implants.
  • To provide practical techniques to improve the validity of evidence in orthopaedic implant research.

Main Methods:

  • Discusses common hurdles in orthopaedic randomized trials.
  • Proposes specific techniques to mitigate these challenges.
  • Emphasizes proactive protocol development for consistent follow-up.

Main Results:

  • The proposed techniques can significantly ease the burdens of conducting high-quality research.
  • While not eliminating all challenges, these methods enhance the feasibility of rigorous implant evaluation.
  • Implementation of expertise-based randomization and objective, independent assessment is key.

Conclusions:

  • Addressing methodological challenges can improve the quality and quantity of orthopaedic implant research.
  • These strategies can help bridge the gap between observational data and higher-validity evidence.
  • Adopting these tips can lead to more reliable data for orthopaedic clinical decisions.