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Increased coronary intervention rate among diabetic patients with poor glycaemic control: a cross-sectional study

Süha Çetin1, Mehmet Akif Öztürk2, Nadir Barındık1

  • 1Department of Cardiology, 29 Mayıs Hospital, Dikmen Caddesi, No:312, 06460 Ankara, Turkey.

Bosnian Journal of Basic Medical Sciences
|March 4, 2014
PubMed

Insights

Poor glycaemic control in type 2 diabetes mellitus (T2DM) is linked to a higher need for coronary artery revascularization. Maintaining good Hemoglobin A1c (HbA1c) levels is crucial for reducing cardiovascular events in T2DM patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • The link between glycaemic control and coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) remains debated.
  • Diabetic patients face a significantly elevated risk of cardiovascular complications, including CAD.

Purpose of the Study:

  • To investigate the association between Hemoglobin A1c (HbA1c) levels and the requirement for coronary revascularization in T2DM patients.
  • To determine if poor glycaemic control independently predicts the need for revascularization in this population.

Main Methods:

  • A cross-sectional study included 301 T2DM patients undergoing coronary angiography for CAD symptoms.
  • Patients were stratified into good (HbA1c ≤ 7%) and poor (HbA1c > 7%) glycaemic control groups.
  • Logistic regression analysis adjusted for relevant clinical factors was performed.

Main Results:

  • A higher revascularization rate (46.6%) was observed in patients with poor glycaemic control compared to those with good control (28.0%; p=0.002).
  • Poor glycaemic control (HbA1c > 7%) was an independent predictor of revascularization (OR 2.26; p=0.003).
  • A linear correlation was found between HbA1c values and the number of affected coronary arteries (r=0.169; p=0.003).

Conclusions:

  • Poor glycaemic control is significantly associated with an increased need for coronary revascularization in T2DM patients.
  • These findings underscore the importance of optimizing glycaemic control for cardiovascular risk reduction in T2DM.
  • Consideration of glycaemic status is vital for both primary and secondary prevention strategies in T2DM-related CAD.

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