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Treatment of patients with neuropathy and anti-MAG IgM M-proteins
E Nobile-Orazio1, L Baldini, S Barbieri
1Institute of Clinical Neurology, University of Milan, Italy.
Annals of Neurology
|July 1, 1988
Abstract:
Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.