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Updated: May 2, 2026
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
[Open construction of experimental abdominal aortic aneurysm swine models with Dacron patch for evaluating
Wei-wei Wu1, Xue-ying Jiang2, Bao Liu1
1Department of Vascular Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100032, China.
Objective:
To construct an experimental abdominal aortic aneurysm (AAA) swine model with Dacron patch for evaluating endovascular aneurysm repair (EVAR) technique.
Methods:
The experimental pigs were generally anesthetized for the open procedure of an aneurysm model creation with Dacron and subsequent arteriography and EVAR with stent graft. Repeat arteriography was performed after 3-month follow-up.
Results:
AAA models were successfully constructed in all 10 experimental pigs. The average aneurysm diameter was (26.3±3.1)mm, increasing by (15.7±3.1)mm comparing to the primary aorta diameter (10.5±0.4)mm. The aorta diameter before and after the experiment showed significant difference (P<0.001). All the animals were survived after the procedure. One swine died 24 hours after the subsequent EVAR because the covering of both renal arteries by the stent graft. The rest 9 animals survived well after the whole operation and 3-month follow-up. The surviving rates at 1 month and 3 months after the operation were both 90%. One type 2 endoleak (10%) was observed after the EVAR, which disappeared at 3-month follow-up.
Conclusions:
Open construction of experimental AAA swine models with Dacron patch is safe and feasible. The model can be used in the developing new EVAR techniques and implant training.
