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Updated: May 2, 2026
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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
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Gonadal dysfunction in morbidly obese adolescent girls
Vivian Chin1, Marisa Censani1, Shulamit Lerner1
1Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
Fertility and Sterility
|March 4, 2014
Summary
Polycystic ovary syndrome (PCOS) and metabolic syndrome (MeS) were evaluated in morbidly obese adolescent girls. Findings indicate PCOS and its components are not associated with MeS in this population, unlike in obese adults.
Area of Science:
- Adolescent Endocrinology
- Reproductive Health
- Metabolic Disorders
Background:
- Morbid obesity in adolescents is linked to various health issues.
- Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in reproductive-aged women.
- Metabolic Syndrome (MeS) is a cluster of conditions increasing cardiovascular risk.
Purpose of the Study:
- To describe gonadal dysfunction in morbidly obese adolescent girls.
- To evaluate the prevalence of PCOS and its association with MeS in this population.
Main Methods:
- Cross-sectional study of 174 adolescent girls (98 included).
- Data collected: height, weight, waist circumference, Tanner stage, hormones, metabolic markers, and menstrual history.
- PCOS diagnosed by NIH criteria; MeS by modified Cook criteria.
Main Results:
- 33% of participants had MeS.
- PCOS was diagnosed in 24 girls (24.5%).
- PCOS and its components were not significantly associated with MeS after adjusting for BMI.
Conclusions:
- In contrast to obese adults, PCOS and its individual components were not associated with MeS in this cohort of untreated morbidly obese adolescent girls.
- This suggests unique pathophysiological mechanisms in adolescent obesity regarding PCOS and MeS.
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