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Protective effect of trimetazidine on amikacin-induced ototoxicity in rats

Fadlullah Aksoy1, Remzi Dogan1, Orhan Ozturan1

  • 1Bezmialem Vakif University, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.

International Journal of Pediatric Otorhinolaryngology
|March 4, 2014
PubMed
Abstract

Insights

Trimetazidine protects against amikacin-induced ototoxicity. This study shows trimetazidine preserves hearing function and reduces oxidative stress caused by amikacin in rats.

Area of Science:

  • Ototoxicity and audiology research.
  • Pharmacology of antibiotic-induced hearing loss.

Background:

  • Aminoglycoside antibiotics, like amikacin, can cause hearing loss.
  • Trimetazidine possesses antioxidant and cytoprotective properties.

Purpose of the Study:

  • To investigate the protective effects of trimetazidine against amikacin-induced ototoxicity.
  • To assess the impact of trimetazidine on hearing function and oxidative stress markers.

Main Methods:

  • Thirty-two male rats were divided into four groups: amikacin, amikacin + trimetazidine, trimetazidine, and control.
  • Animals received daily oral trimetazidine (10 mg/kg) or intramuscular amikacin (600 mg/kg) for 14 days.
  • Hearing was assessed using distortion product otoacoustic emissions (DPOAE) and auditory brainstem response (ABR); biochemical parameters evaluated oxidative status.

Main Results:

  • Amikacin significantly reduced DPOAE values and increased ABR thresholds compared to the control and trimetazidine + amikacin groups.
  • Oxidative stress markers (TOS, OSI) were elevated in the amikacin group, while antioxidant status (TAS) was reduced.
  • Trimetazidine administration mitigated amikacin's negative effects on hearing and oxidative balance.

Conclusions:

  • Trimetazidine demonstrates a protective effect against amikacin-induced ototoxicity.
  • The findings suggest trimetazidine's antioxidant properties play a role in preventing aminoglycoside-induced hearing damage.
Keywords:
ABRAmikacinDPOAEOxidative statusTrimetazidine

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