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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Diseases of the Liver and Gallbladder01:26

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
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Cellular therapy for liver disease.

Robert C Huebert1, Jorge Rakela2

  • 1Gastroenterology Research Unit, Mayo Clinic, Rochester, MN.

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|March 4, 2014
PubMed
Summary
This summary is machine-generated.

Regenerative medicine offers new hope for liver disease. Cell-based therapies, including stem cells, are being explored to overcome limitations of current treatments like liver transplants.

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Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Stem Cell Biology

Background:

  • The liver possesses significant regenerative capabilities, making hepatology a leader in regenerative medicine.
  • Current liver disease treatments like transplantation face challenges including donor organ shortages and limited applicability.

Purpose of the Study:

  • To review cell-based therapy strategies for liver diseases.
  • To discuss ongoing research and clinical trials in liver regeneration.
  • To identify key questions for advancing cell therapies to clinical translation.

Main Methods:

  • Review of scientific rationale for cell therapies in animal models.
  • Analysis of cell therapies tested in human clinical trials.
  • Discussion of stem cell types including hepatocytes, liver stem/progenitor cells, and bone marrow-derived stem cells.

Main Results:

  • Cellular therapy is a promising avenue for acute and chronic liver diseases.
  • Understanding liver regeneration mechanisms supports rational cell-based approaches.
  • Induced pluripotent stem cells show potential for personalized regenerative therapy.

Conclusions:

  • Cell-based therapies hold significant potential to transform liver disease treatment.
  • Further research is needed to address challenges in clinical translation of these therapies.
  • Advances in stem cell technology offer future personalized regenerative options for liver disease.