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Related Experiment Video

Updated: May 2, 2026

Porcine Normothermic Isolated Liver Perfusion
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Isolated hepatic perfusion: principles and results.

O Facy1, A Doussot2, F Zinzindohoué3

  • 1Service de chirurgie digestive et cancérologique, CHU Bocage Central, 14, rue Gaffarel, 21000 Dijon, France; Inserm 866, équipe « thérapie locorégionale en cancérologie », Dijon, France.

Journal of Visceral Surgery
|March 4, 2014
PubMed
Summary

Isolated hepatic perfusion delivers high-dose chemotherapy for unresectable liver tumors, showing promising response rates but with significant morbidity. This technique offers a new therapeutic option for liver cancer patients in clinical trials.

Keywords:
Colorectal cancerIsolated hepatic perfusionLiver metastasesLocoregional chemotherapyOcular melanomaPercutaneous hepatic perfusion

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Isolated hepatic perfusion (IHP) enables targeted high-dose chemotherapy delivery to liver tumors, minimizing systemic toxicity.
  • This technique is primarily indicated for patients with surgically unresectable primary or secondary liver malignancies.
  • IHP involves temporary liver vascular exclusion, with chemotherapy administered via arterial and/or portal routes.

Purpose of the Study:

  • To evaluate the efficacy and safety of isolated hepatic perfusion for unresectable liver tumors.
  • To assess response rates, morbidity, and mortality associated with IHP.
  • To position IHP as a potential therapeutic alternative within clinical trials.

Main Methods:

  • Liver vascular exclusion, with or without shunts, followed by chemotherapy infusion (e.g., melphalan, oxaliplatin).
  • Perfusion circuits can be open or closed, with or without oxygenation, lasting 30-90 minutes.
  • Percutaneous techniques with incomplete exclusion are also explored.

Main Results:

  • Response rates (partial response or stabilization) range from 60% to 80% in larger series.
  • Complete morphologic responses are observed in approximately 5% of patients.
  • Morbidity and mortality rates are reported at 40% and 5%, respectively, encompassing procedure- and chemotherapy-related complications.

Conclusions:

  • Isolated hepatic perfusion represents a developing therapeutic strategy for unresectable liver tumors.
  • Promising response rates suggest potential benefit, but the associated morbidity requires careful consideration.
  • IHP can be offered to eligible patients within clinical trials for liver cancer treatment.