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Updated: May 2, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides
Qin Ren1, Kana Tsunaba2, Yoshiaki Kitamura3
1United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Abstract:
Positron emission tomography (PET) is a highly sensitive quantitative imaging technique for studying molecular pathways and interactions in vivo. This imaging technique plays a key role in drug discovery, pharmacokinetics, pharmacodynamics, and assessing in vivo distribution. In this study, we designed an ethynylbenzene-substituted glycol (M(E)) as a versatile probe for PET labeling of oligonucleotides through a click reaction.
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