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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment02:17

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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
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Network dynamics in the tumor microenvironment.

Hamid Bolouri1

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, USA.

Seminars in Cancer Biology
|March 4, 2014
PubMed
Summary
This summary is machine-generated.

Understanding cancer evolution requires viewing tumor cells as part of a complex ecosystem. New computational models of the tumor microenvironment can identify drug targets and guide experiments.

Keywords:
Big DataBioinformaticsComputational biologyModelingNetwork biologySystems biologyTumor microenvironment

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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Area of Science:

  • Oncology
  • Systems Biology
  • Computational Biology

Background:

  • Cancer progression involves complex interactions within the tumor microenvironment (TME).
  • The TME, a multi-species ecosystem, influences tumor growth, dormancy, and resistance to therapies.

Purpose of the Study:

  • To review the role of the TME as a distinct cellular ecosystem in cancer evolution.
  • To highlight the trend and potential of data-rich, molecularly detailed computational models of the TME.

Main Methods:

  • Review of current scientific literature on tumor microenvironment interactions.
  • Analysis of emerging high-throughput technologies for data generation.
  • Discussion of computational modeling approaches for TME analysis.

Main Results:

  • Interactions among diverse cells in the TME create unique environments promoting tumor growth and resistance.
  • Computational models of the TME are increasingly data-rich and molecularly detailed.
  • These models can identify mechanisms of cancer dysregulation and suggest therapeutic strategies.

Conclusions:

  • Viewing cancer as a multi-species ecosystem within the TME is crucial for understanding its evolutionary path.
  • Data-driven, molecularly detailed TME models offer powerful tools for pinpointing drug targets and experimental directions.