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A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse

Min Qiang1, Rong Xiao2, Tao Su1

  • 1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.

Journal of Alzheimer'S Disease : JAD
|March 4, 2014
PubMed
Summary

Formaldehyde accumulation in the brain, linked to altered metabolism of enzymes like SSAO and ADH3, may drive cognitive decline in Alzheimer's disease (AD). This study in a mouse model reveals a potential cause for AD-related dementia.

Keywords:
ADH3Alzheimer's diseaseSAMP8SAMR1SSAOenzymesformaldehydemetabolism

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