Related Experiment Video

Updated: May 2, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.6K

Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical

Yuichi Ozaki1, Toshio Imanishi1, Ikuko Teraguchi1

  • 1Department of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, Japan.

Atherosclerosis
|March 4, 2014
PubMed

Insights

P-selectin glycoprotein ligand-1 (PSGL-1) on CD14++CD16+ monocytes is elevated in acute coronary syndrome (ACS) patients with plaque rupture and thrombus. This suggests PSGL-1 up-regulation on this monocyte subset is key to ACS progression.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Biomedical Engineering

Background:

  • Monocytes are heterogeneous and implicated in acute coronary syndrome (ACS).
  • The role of specific monocyte subsets in plaque rupture and thrombus formation is unclear.
  • P-selectin glycoprotein ligand-1 (PSGL-1) is linked to monocyte activation in thrombosis.

Purpose of the Study:

  • To investigate the relationship between PSGL-1 expression on monocyte subsets and thrombus formation in ACS patients.
  • To determine if PSGL-1 expression differs among monocyte subsets in ACS.
  • To correlate PSGL-1 expression with plaque rupture and thrombus presence.

Main Methods:

  • 100 individuals studied: ACS patients (AMI, UAP, stable angina) and controls.
  • Monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16+) and PSGL-1 expression measured via flow cytometry.
  • Frequency-domain optical coherence tomography (FD-OCT) used in AMI and UAP patients.

Main Results:

  • CD14++CD16+ monocytes showed higher PSGL-1 expression in ACS patients compared to other subsets.
  • PSGL-1 expression on CD14++CD16+ monocytes was significantly elevated in acute myocardial infarction (AMI) patients.
  • Higher PSGL-1 levels on CD14++CD16+ monocytes correlated with plaque rupture and intracoronary thrombus.

Conclusions:

  • Up-regulation of PSGL-1 on CD14++CD16+ monocytes is associated with plaque rupture and thrombus formation in ACS.
  • PSGL-1 on CD14++CD16+ monocytes may play a critical role in ACS pathogenesis.
  • This finding highlights a potential therapeutic target for ACS.
Abstract

Keywords:
Acute coronary syndromeOptical coherence tomographyPSGL-1Thrombus

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.1K
Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography11:45

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

Published on: May 26, 2015

9.3K

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
943
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
495
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
2.1K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
948