Related Experiment Video
Updated: May 2, 2026
In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
Bcl-6 controlled TFH polarization and memory: the known unknowns
1Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, School of Life Sciences, Tsinghua University, Beijing 100084, PR China.
Abstract:
Upon antigenic activation in vivo, naïve CD4 T cells can differentiate into one of several helper (Th) subsets under the control of lineage-specifying transcription factors to tailor immune responses against different types of pathogens. Follicular T-helper (TFH) cells are a recently defined subset that is controlled by Bcl-6 and specializes in promoting B cell-mediated humoral immunity. TFH cells exhibit unique spatiotemporal and functional features, but it is not settled as to how Bcl-6 promotes the TFH development, how TFH cells relate to other Th subsets, and how TFH cells relate to memory. Here we review recent advances and crucial gaps in our understanding of Bcl-6-controlled TFH development and function.
More Related Videos
05:03Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
Published on: April 26, 2024
07:39Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
Published on: January 7, 2019
Related Concept Videos
01:22T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
01:24B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...