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Updated: May 2, 2026

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
Published on: August 9, 2022
Multiple coronary fistulae to left ventricle, with acute myocardial infarction
Ihsan Sami Uyar1, Besir Akpinar2, Omer Senarslan3
1Cardiovascular Surgery Department, Sifa University, Izmir, Turkey ihsansami@hotmail.com.
Insights
A rare case of myocardial infarction was caused by multiple abnormal coronary artery connections (fistulae). These fistulae drained into the left ventricle, leading to reduced blood flow in the heart muscle.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Radiology
Background:
- Coronary artery fistulae are rare congenital or acquired abnormalities.
- Myocardial infarction (MI) is typically caused by atherosclerosis, but other causes exist.
Observation:
- A patient presented with myocardial infarction.
- Coronary angiography revealed multiple coronary artery fistulae.
- These fistulae originated from the left anterior descending, right coronary, and circumflex arteries.
- The fistulae drained directly into the left ventricle.
Findings:
- A myocardial perfusion scan demonstrated a fixed perfusion defect, indicating irreversible damage to the heart muscle.
- The anatomical findings suggest the fistulae were the cause of the MI.
Implications:
- This case highlights coronary artery fistulae as a potential, albeit rare, cause of myocardial infarction.
- Accurate diagnosis via angiography is crucial for appropriate management.
- Understanding these rare vascular anomalies is important for cardiovascular specialists.
Abstract:
A rare case of myocardial infarction secondary to multiple coronary artery fistulae is described. Coronary angiography showed the fistulae originating from the distal septal branch of the left anterior descending artery and distal branches of the right coronary and circumflex arteries, and drained into the left ventricle. A myocardial perfusion scan showed a fixed perfusion defect.
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