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Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
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Defeating the pores of Kohn.
Calvin S H Ng1, Rainbow W H Lau, Kelvin K W Lau
1Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.
Asian Cardiovascular & Thoracic Annals
|March 4, 2014
Summary
Complete lobe treatment is crucial for effective emphysema management using endobronchial valves. Incomplete treatment can lead to prolonged lung collapse failure, highlighting the importance of addressing collateral ventilation.
Area of Science:
- Pulmonary Medicine
- Interventional Pulmonology
Background:
- Emphysema treatment often involves endobronchial valves for lung volume reduction.
- Achieving adequate atelectasis is key for successful outcomes.
Observation:
- A case demonstrated treatment failure due to incomplete lobar coverage with endobronchial valves.
- Intralobar collateral ventilation via the pores of Kohn was identified as a contributing factor.
Findings:
- Blockage of the remaining anterior segment after initial valve placement led to successful atelectasis.
- This intervention resulted in significant improvements in the patient's pulmonary function.
Implications:
- This case underscores the necessity of complete lobar treatment for endobronchial valve therapy in emphysema.
- Addressing intralobar collateral ventilation is critical for optimizing treatment efficacy and preventing failure.
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