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Related Experiment Video

Updated: May 2, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
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Intestinal adaptation following resection.

Kelly A Tappenden1

  • 1Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois.

JPEN. Journal of Parenteral and Enteral Nutrition
|March 4, 2014
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Summary

Intestinal adaptation enhances nutrient absorption after bowel resection. Recent findings show adult patients with short bowel syndrome (SBS) can achieve enteral autonomy, even after long-term parenteral nutrition (PN) dependence, especially with trophic stimulation.

Keywords:
intestinal adaptationintestinal resectionmalabsorptionshort bowel syndrome

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Area of Science:

  • Gastroenterology
  • Surgical Outcomes
  • Regenerative Medicine

Background:

  • Intestinal adaptation is a compensatory process following bowel resection, improving absorption in remnant bowel.
  • Animal studies show structural and functional changes, but human data and mechanisms are less understood.
  • Factors like resection extent, enteral nutrition, and growth factors influence adaptation.

Purpose of the Study:

  • To review the mechanisms and influencing factors of intestinal adaptation.
  • To discuss the role of intestinotrophic factors like teduglutide and somatropin in short bowel syndrome (SBS).
  • To highlight recent findings on long-term adaptation and enteral autonomy in adult SBS patients.

Main Methods:

  • Literature review of animal and human studies on intestinal adaptation.
  • Analysis of clinical data regarding the efficacy of teduglutide and somatropin.
  • Synthesis of recent evidence on long-term outcomes in short bowel syndrome.

Main Results:

  • Intestinal adaptation involves bowel lengthening, thickening, increased villus height, and enhanced nutrient transporter expression.
  • Teduglutide and somatropin are approved agents that improve fluid absorption and reduce parenteral nutrition (PN) needs.
  • Contrary to previous beliefs, adult SBS patients can achieve enteral autonomy years after PN dependence, particularly with trophic stimulation.

Conclusions:

  • Intestinal adaptation is a complex process crucial for managing short bowel syndrome.
  • Growth factors offer significant benefits in enhancing intestinal function and reducing PN dependency.
  • Extended periods of adaptation and potential for enteral autonomy in adult SBS patients warrant further investigation and clinical consideration.