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High free fatty acid level is associated with recurrent stroke in cardioembolic stroke patients

Jeong-Yoon Choi1, Ji-Sun Kim, Ji Hyun Kim

  • 1From the Department of Neurology (J.-Y.C.), Korea University College of Medicine, Korea University Ansan Hospital, Ansan; Department of Neurology (J.-S.K.), Korea University College of Medicine, Korea University Anam Hospital, Seoul; and Department of Neurology (J.H., K.O., S.-B.K., W.-K.S.), Korea University College of Medicine, Korea University Guro Hospital, Seoul.

Neurology
|March 4, 2014
PubMed

Insights

Elevated free fatty acid (FFA) levels are linked to cardioembolic (CE) stroke. Higher FFA may predict recurrent stroke in CE patients, offering a potential biomarker for risk stratification.

Area of Science:

  • Cardiology
  • Neurology
  • Biochemistry

Background:

  • Cardioembolic (CE) stroke is a significant cause of recurrent cerebrovascular events.
  • Plasma free fatty acid (FFA) levels have been implicated in various cardiovascular conditions.
  • The association between FFA and stroke recurrence, particularly in CE stroke, requires further investigation.

Purpose of the Study:

  • To investigate the relationship between plasma FFA levels and the risk of recurrent stroke in patients with CE stroke.
  • To compare FFA levels in CE stroke patients versus non-CE stroke patients.
  • To determine if elevated FFA is an independent predictor of stroke recurrence in CE stroke.

Main Methods:

  • Retrospective analysis of 669 acute ischemic stroke patients.
  • Measurement of baseline plasma FFA concentrations.
  • Multivariate logistic regression analysis to assess associations, with a mean follow-up of 25.4 months.

Main Results:

  • CE stroke patients exhibited approximately 1.5-fold higher baseline FFA levels than non-CE stroke patients.
  • Elevated FFA was significantly associated with CE stroke (HR 2.124).
  • In CE stroke patients, elevated FFA was independently associated with stroke recurrence (HR 2.711), but not in non-CE stroke patients.

Conclusions:

  • Elevated plasma FFA levels are associated with CE stroke.
  • Increased FFA concentration may serve as a predictive indicator for recurrent stroke in CE stroke patients.
  • This finding highlights FFA as a potential biomarker for risk stratification in CE stroke management.
Abstract

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