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The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
Dogan Atilgan1, Bekir S Parlaktas1, Nihat Uluocak1
1Department of Urology, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
This study found that the MnSOD Ala16Val polymorphism is associated with an increased risk of renal cell carcinoma (RCC) in Turkish patients. The Ala allele and specific genotypes suggest a genetic susceptibility to developing this cancer.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Renal cell carcinoma (RCC) is a significant global health concern.
- Genetic factors play a role in cancer susceptibility.
- The MnSOD Ala16Val polymorphism is a potential genetic marker.
Purpose of the Study:
- To investigate the association between the MnSOD Ala16Val polymorphism and RCC in Turkish patients.
- To determine if specific genotypes or alleles increase the risk of developing RCC.
Main Methods:
- A case-control study involving 41 RCC patients and 50 healthy Turkish volunteers.
- DNA genotyping of serum samples for MnSOD polymorphism.
- Statistical analysis of genotype frequencies, allele frequencies, and odds ratios.
Main Results:
- Significant differences in MnSOD genotype distributions were observed between RCC patients and controls.
- Ala/Ala+Ala/Val genotypes were associated with a higher risk of RCC (OR=2.64, P=0.039).
- The Ala allele was also significantly associated with increased RCC risk (OR=2.26, P=0.009).
Conclusions:
- The MnSOD Ala16Val polymorphism may contribute to genetic susceptibility for renal cell carcinoma in the Turkish population.
- This polymorphism could be a potential biomarker for RCC risk assessment.
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