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Brooke-spiegler syndrome: a rare entity.

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  • 1Teerthanker Mahaveer Medical College and Research Center, Moradabad 244001, India.

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Brooke-Spiegler syndrome, a rare autosomal dominant condition, presents with multiple skin tumors. This case highlights a 40-year-old female with scalp trichoepitheliomas and cylindromas, emphasizing the syndrome

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Area of Science:

  • Dermatology
  • Genetics
  • Oncology

Background:

  • Brooke-Spiegler syndrome is a rare autosomal dominant disorder.
  • It is characterized by the development of multiple trichoepitheliomas, cylindromas, and other adnexal tumors.
  • Few cases are documented in medical literature.

Purpose of the Study:

  • To report a rare case of Brooke-Spiegler syndrome.
  • To describe the clinical presentation and histopathological findings.
  • To contribute to the limited literature on this rare condition.

Main Methods:

  • Clinical examination of a 40-year-old female patient.
  • Histopathological examination of scalp lesions.
  • Diagnosis based on clinical history and pathology.

Main Results:

  • The patient presented with multiple trichoepitheliomas and cylindromas on the scalp.
  • Histopathological examination confirmed the diagnosis.
  • The findings are consistent with Brooke-Spiegler syndrome.

Conclusions:

  • Brooke-Spiegler syndrome is a rare genetic disorder.
  • This case underscores the importance of recognizing its clinical and histopathological features.
  • Further case reports are valuable for understanding this rare entity.