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Updated: May 2, 2026

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Catalytic Radical Domino Reactions in Organic Synthesis
Leanne J Sebren1, James J Devery1, Corey R J Stephenson1
1Department of Chemistry, University of Michigan, Ann Arbor, MI.
Abstract:
Catalytic radical-based domino reactions represent important advances in synthetic organic chemistry. Their development benefits synthesis by providing atom- and step-economical methods to complex molecules. Intricate combinations of radical, cationic, anionic, oxidative/reductive, and transition metal mechanistic steps result in cyclizations, additions, fragmentations, ring-expansions, and rearrangements. This Perspective summarizes recent developments in the field of catalytic domino processes.
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