Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

12.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.5K
Healing I: Introduction01:11

Healing I: Introduction

14
Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
14
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.4K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.8K
Inflammation01:38

Inflammation

46.6K
Overview
46.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Surgical Approach for Wound Closure of Large Livedoid Vasculopathy Wounds: A Case Series.

Advances in skin & wound care·2026
Same author

A precision-based approach for bioactive skin allograft application in nonhealing wounds using bacterial fluorescence imaging.

Wounds : a compendium of clinical research and practice·2025
Same author

Adaptive surgical approach to giant inguinoscrotal hernia with enterocutaneous fistula in an adult paraplegic male with severe lordoscoliosis causing loss of domain: A case report and review of literature.

International journal of surgery case reports·2025
Same author

Compression therapy in peripheral artery disease: a literature review.

Journal of wound care·2023
Same author

Filgrastim, fibrinolysis, and neovascularization.

Journal of tissue engineering and regenerative medicine·2022
Same author

The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care.

International journal of radiation biology·2020

Related Experiment Video

Updated: May 2, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

9.2K

Stem Cells and Healing: Impact on Inflammation.

William J Ennis1, Audrey Sui2, Amelia Bartholomew3

  • 1Department of Vascular Surgery, University of Illiniois Hospital and Health Sciences System , Chicago, Illinois. ; Department of Wound Healing and Tissue Repair, University of Illiniois Hospital and Health Sciences System , Chicago, Illinois. ; Department of Surgery, University of Illiniois Hospital and Health Sciences System , Chicago, Illinois.

Advances in Wound Care
|March 4, 2014
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for nonhealing wounds, but challenges remain. Preactivating MSCs with inflammatory cytokines may enhance their therapeutic potential for wound healing.

More Related Videos

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.9K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

11.7K

Related Experiment Videos

Last Updated: May 2, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

9.2K
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.9K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

11.7K

Area of Science:

  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Nonhealing wounds are a growing global health concern, driven by aging populations, obesity, diabetes, and increased surgical procedures.
  • Chronic inflammation is a key factor in nonhealing wounds at the micro-level.
  • Current treatments include energy-based modalities, scaffoldings, mechano-transduction, growth factors, and cell-based therapies.

Approach:

  • Mesenchymal stem cells (MSCs) are being investigated for their potential to improve wound healing.
  • The immune-modulating properties of MSCs make them attractive therapeutic candidates.
  • This review examines the literature on stem cell therapy for wound healing, focusing on MSCs.

Key Points:

  • Limitations of current stem cell therapy include high cell dosage requirements, complex delivery, and poor cell retention.
  • Variability in cell preparation, passage number, and micro-environmental factors complicate comparisons of in vitro and clinical studies.
  • Preactivation of MSCs with inflammatory cytokines like TNF-alpha or IFN-gamma may enhance their efficacy.

Conclusions:

  • MSCs hold promise for treating nonhealing wounds.
  • Preactivation strategies could overcome current limitations and improve MSC therapeutic benefits.
  • Further research into MSC preactivation is crucial for advancing wound healing therapies.