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Oncogenes in human leukemias.

A Butturini1, E Sthivelman, E Canaani

  • 1Department of Pediatrics, UCLA School of Medicine.

Cancer Investigation
|January 1, 1988
PubMed
Summary
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Cellular oncogenes regulate cell growth but can cause leukemia when activated by genetic changes. This review explores oncogene activation in human leukemia, discussing mechanisms and therapeutic potential.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Cellular oncogenes (proto-oncogenes) are crucial for normal eukaryotic cell growth and development.
  • Aberrant activation of these genes, often through viral transduction, is linked to leukemia development in animals.

Purpose of the Study:

  • To review the role of cellular oncogene activation in the pathogenesis of human leukemia.
  • To explore the mechanisms by which oncogene activation contributes to leukemogenesis.
  • To discuss the diagnostic and therapeutic implications of oncogene activation in leukemia.

Main Methods:

  • Literature review of studies implicating oncogene activation in human leukemia.
  • Analysis of proposed mechanisms of oncogene activation (e.g., mutation, translocation, gene fusion).

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Main Results:

  • Various genetic alterations, including point mutations, chromosomal translocations, and formation of chimeric genes, can activate cellular oncogenes.
  • Activated oncogenes are implicated in the development of human leukemia.

Conclusions:

  • Oncogene activation is a significant factor in human leukemia pathogenesis.
  • Understanding these mechanisms offers potential for novel diagnostic markers and therapeutic strategies for leukemia.