Related Experiment Video
Updated: May 2, 2026
08:01
Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Published on: November 30, 2022
7.3K
Biobanks and personalized medicine.
J E Olson1, S J Bielinski, E Ryu
1Department of Health Sciences Research, Rochester, MN, USA.
Clinical Genetics
|March 5, 2014
Summary
Biobanks are crucial infrastructure for advancing clinical genetics and personalized medicine. Well-designed biobanks facilitate research by collecting and linking biospecimens and health data, supporting genetic discoveries.
Area of Science:
- Genetics
- Biobanking
- Personalized Medicine
Background:
- Biobanks are essential for clinical genetics research.
- Personalized medicine relies on robust data infrastructure.
- The role of biobanks in advancing genetic medicine is growing.
Purpose of the Study:
- To review the role of biobanks in supporting clinical genetics.
- To discuss the establishment and utilization of biobanks for personalized medicine.
- To highlight key considerations and challenges in biobanking for genetic research.
Main Methods:
- Mini-review of existing literature and practices.
- Discussion of biobank types (disease-specific vs. general).
- Analysis of biobank setup considerations (consenting, governance, data, informatics, EHR linkage).
Main Results:
- Biobanks offer critical infrastructure for personalized medicine.
- Key considerations include biospecimen handling, data management, and phenotyping.
- Uses include genotype-driven recruitment and gene-environment studies.
Conclusions:
- Carefully designed biobanks are vital for clinical genetics.
- Biobanks support personalized medicine through data and biospecimen resources.
- Ongoing challenges include research result return and long-term sustainability.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:50Combination Therapies and Personalized Medicine
1.5K
1.5K
01:29Issues And Trends In Healthcare Delivery System
6.5K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.5K
01:29Pharmacogenomics: Identification of New Drug Targets
121
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121
01:29Pharmacogenetics and Pharmacogenomics: Overview
253
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
253
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
159
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
159