Do anti-angiogenic cancer therapies increase risk of significant weight loss?

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Shuang Zhang1, Min Yu, Yuquan Wei

  • 1Sichuan University, West China Hospital, State Key Laboratory of Biotherapy and Cancer Center , Chengdu 610041 , China.

Expert Opinion on Drug Safety
|March 5, 2014
PubMed
Abstract

Insights

Anti-angiogenic cancer therapies generally do not cause significant weight loss, offering a favorable safety profile. However, some multikinase inhibitors in clinical trials showed a potential association, requiring further investigation.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Angiogenesis plays a critical role in various diseases, notably cancer.
  • Anti-angiogenic drugs are widely used in cancer treatment.
  • Current anti-angiogenic therapies can lead to patient adverse effects.

Purpose of the Study:

  • To review the evidence linking anti-angiogenic therapies with weight loss.
  • To analyze data from basic experiments and clinical trials on weight changes during anti-angiogenic cancer treatment.

Main Methods:

  • Literature review of studies investigating anti-angiogenic therapies and weight loss.
  • Analysis of data from preclinical experiments and human clinical trials.

Main Results:

  • Limited strong associations between most anti-angiogenic cancer therapies and weight loss were identified.
  • An exception was noted for certain multikinase inhibitors evaluated in clinical trials.

Conclusions:

  • Anti-angiogenic cancer therapies demonstrate a generally safe profile concerning weight loss.
  • Further clinical trials are necessary to definitively establish the relationship between these therapies and weight changes.

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