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Updated: May 2, 2026

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
Published on: May 19, 2017
Ca(2+) release-activated Ca(2+) channel inhibitors
Paolo Pevarello1, Silvia Cainarca, Chiara Liberati
1Axxam Discovery Chemistry, Via Castellino, 111, 80100 Napoli, Italy.
Abstract:
Ca(2+) release-activated Ca(2+) (CRAC) channels are becoming important targets for therapeutic intervention in several areas of disease, including immunology, allergy and cancer. In parallel to the progression towards reliable methods for measuring CRAC currents and their inhibition, patents have been generated by several companies. In this Patent Review, an analysis of the patents in the CRAC channel inhibition filed is presented. A discussion of the biological methods used in the patents is included. The general interest in this area is growing fast with almost 80% of the patents issued after 2010.
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