Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute phase reactants in the elderly.

N Milman1, N Graudal, H C Andersen

  • 1Department of Medicine P, Bispebjerg Hospital, Copenhagen, Denmark.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 15, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of monotherapy with conventional synthetic disease-modifying anti-rheumatic drugs or glucocorticoids on radiographic progression in rheumatoid arthritis: a network meta-analysis of 64 treatment arms from 31 randomized controlled trials.

Scandinavian journal of rheumatology·2026
Same author

Clinical and biochemical presentation of sarcoidosis with high and normal serum angiotensin-converting enzyme.

Scandinavian journal of rheumatology·2018
Same author

Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement.

Transfusion medicine (Oxford, England)·2017
Same author

Correction: Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.

PloS one·2016
Same author

Clinicians' perspective on key domains in ANCA-associated vasculitis: a Delphi exercise.

Scandinavian journal of rheumatology·2016
Same author

Correlations Between Iron Status Markers During Normal Pregnancy in Women with and without Iron Supplementation.

Hematology (Amsterdam, Netherlands)·2016
Same journal

Reference intervals for venous blood gas measurement in a healthy Chinese population.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approach.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Development and validation of patient-based exponentially weighted moving average quality control models for three antipsychotic drugs and their metabolites by LC-MS/MS.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Comparing conventional correction formulas and machine learning-based prediction of ionized calcium.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Micro- and nanoplastics as emerging clinical analytes: analytical validation, interpretive uncertainty, and laboratory actionability in human specimens.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Performance of Free Light Chain reagents in the Dutch External Quality Assessment programme over the past 14 years.

Clinica chimica acta; international journal of clinical chemistry·2026
See all related articles

Healthy elderly individuals exhibit elevated levels of key acute phase reactants, including erythrocyte sedimentation rate (ESR) and fibrinogen, compared to younger adults. These inflammatory markers show significant correlations, suggesting a link in aging.

Area of Science:

  • Biochemistry
  • Gerontology
  • Immunology

Background:

  • Acute phase reactants (APRs) are proteins whose plasma concentrations increase or decrease in response to inflammation.
  • Aging is associated with a chronic, low-grade inflammatory state, often termed 'inflammaging'.

Purpose of the Study:

  • To compare levels of specific acute phase reactants in healthy elderly versus healthy younger individuals.
  • To investigate potential sex differences and correlations among these reactants in the elderly population.

Main Methods:

  • Measurement of erythrocyte sedimentation rate (ESR), plasma fibrinogen, serum orosomucoid, serum alpha 1-antitrypsin, and serum haptoglobin.
  • Comparative analysis between 267 healthy elderly subjects (median age 79) and 58 healthy younger subjects (median age 27).

Related Experiment Videos

Main Results:

  • All measured acute phase reactants were significantly higher in the elderly group compared to the younger group (p < 0.001 for ESR, fibrinogen, alpha 1-antitrypsin, haptoglobin; p < 0.01 for orosomucoid).
  • No significant sex differences were observed for any of the acute phase reactants in the elderly.
  • Strong positive correlations were found among the acute phase reactants, notably between ESR and fibrinogen (r = 0.53, p < 0.001).

Conclusions:

  • Healthy aging is associated with elevated levels of key acute phase reactants, potentially reflecting a baseline inflammatory state.
  • The findings suggest interconnectedness of these inflammatory markers in older adults and highlight the need for age-specific reference ranges.