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Rhodotorula glutinis meningitis: a case report and review of literature

Sarala Menon1, H R Gupta, R Sequeira

  • 1Department of Microbiology, Grant Government Medical College and Sir J J Hospital, Mumbai, India.

Mycoses
|March 5, 2014
PubMed

Insights

This case study highlights Rhodotorula glutinis meningitis in an HIV-infected patient. Despite initial treatment success, the patient later succumbed to illness, underscoring the challenges of opportunistic infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Rhodotorula, a ubiquitous yeast, is an emerging human pathogen, particularly in immunocompromised individuals.
  • Meningitis caused by Rhodotorula species is rare, with limited reports in HIV-infected patients.

Observation:

  • A case of Rhodotorula glutinis meningitis in an HIV-infected patient with a history of abdominal tuberculosis is presented.
  • Diagnosis was confirmed by cerebrospinal fluid (CSF) Gram staining and culture, with contamination ruled out.
  • Initial treatment with Amphotericin B was successful, leading to patient discharge.

Findings:

  • The patient was readmitted seven months later with severe symptoms and ultimately succumbed to the illness.
  • Post-mortem CSF cultures were negative for Rhodotorula, acid-fast bacilli, and other pyogenic organisms.
  • This represents the first reported isolation of Rhodotorula glutinis from the institute's mycological work-up over 11 years.

Implications:

  • This case emphasizes the potential severity and challenges in managing Rhodotorula meningitis, even with initial therapeutic response.
  • It highlights the need for vigilance in diagnosing and treating opportunistic fungal infections in HIV patients.
  • Further research into Rhodotorula pathogenesis and optimal treatment strategies is warranted.
Keywords:
HIV infectedRhodotorulameningitisopportunistic infectionyeast

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