Related Experiment Video

Updated: May 2, 2026

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
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Published on: May 15, 2014

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Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors

Marilyn J Telen1

  • 1Division of Hematology, Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Box 2615, Durham, NC 27710, USA.

Hematology/Oncology Clinics of North America
|March 5, 2014
PubMed

The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.

Keywords:
AdhesionEndotheliumIntegrinsSelectinsSickle cell disease

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